Efficacy study with forskolin

  • Transdermal permeation of diterpene forskolin, a natural compound isolated from roots of Coleus forskohlii (Briq.), was evaluated in Franz diffusion cell system utilizing skin graft
  • The permeation of forskolin was enhanced when the concentration of Tetrahydropiperine was 5% of forskolin concentration
Time
(min)
Forskolin Release Control
(mg)
Forskolin Release with THP
(mg)
Increase in release
(% of forskolin)
15 1.28 1.64 28.12
30 4.05 5.64 39.25
60 8.45 8.88 5.09

Transdermal permeation of diterpene forskolin in the presence of THP

Effect of THP on the dermal penetration of forskolin