 |
|
 |
 |
| |
| |
|
| |
 |
| |
 |
| |
Cosmoperine or Tetrahydropiperine (THP) is a derivative of the pungent alkaloid, piperine found naturally in Piper nigrum (black pepper). Small amounts of THP (0.7%) have also been identified in natural black pepper oleoresin.
|
|
| |
|
|
| |
|
|
| |
|
|
| |
Piperine is reported to enhance the bioavail-ability of drugs such as rifampicin1, isoniazid2, pyrazinamide2, propranolol3, theophylline3, phenytoin4 and nutrients such as vitamins, minerals, coenzymes, amino acids and nutraceutical herbal extracts, when co-administered orally with these substances5.
In view of these properties, THP is a potential
transdermal “bioavailability” enhancer when
co-administered with drugs/nutrients.* |
|
| |
|
| |
1 Zutshi, U. et al. (1984). J. Assoc. Physicians of India. 33:223-224
2 Zutshi, U. et al. (1989) Indian Patent # 1232/DEU89
3 Bano, C.K. et al. (1991) Eur. J. Clin. Pharm. 41:615-618
4. Atal, C.K. et al. (1977) Indian J. Exp. Biol. 15:1230-1232.
5. Majeed, M. et al. US Patent #5,536,506 (1996), US Patent # 5,744,161 (1998), US Patent #
5,972,382 (1999), US Patent # 6, 054, 585 (2000) and International patents. |
|
| |
|
| |
*US Patent 6,849,645, UK Patent GB2380675 and other International Patents pending
|
|
| |
|
|
| |
|
|
